Intermittent Fasting (IF) is one of the most popular nutrition trends that involves alternating cycles of eating and fasting. It’s an ancient dietary concept that was popularized in 2012, when Dr. Michael Mosley featured it in Eat Fast, Live Longer, a BBC documentary, and The Fast Diet, a book about fasting. Since then, many fitness programs and self-help books have talked about this nutrition trend and spread the word of its effects to the body.1,2
It’s often believed by experts that intermittent fasting can provide health benefits such as improved metabolism, stronger immune system, longevity, enhanced heart and brain function, weight loss, and many others.3,4 With all of these said, what really makes it effective and how does it work?
What is Intermittent Fasting (IF)?
Intermittent fasting is basically an alternating cycle of eating and fasting. This usually involves fasting for 16 hours and eating within an 8-hour window in a day or doing two sets of 24-hour fasting in a week. Unlike other dietary methods, this doesn't specify what food to eat, but when you should eat them.
Also, this method is only the modern version of how people eat in ancient times. Before, our ancestors didn’t have ways to preserve food yet and would frequently go for long periods of time without eating. This developed their ability to hold hunger for survival. This actually makes eating regularly (3-4 meals a day) more unusual compared to occasional fasting.5
Intermittent fasting is more of an alternating cycle of eating and fasting. This has been existing since ancient times when our ancestors can’t preserve food yet or don’t have available food.
Why Should You Undergo Intermittent Fasting?
Doing intermittent fasting is allowing your body to experience an acute, short-term stress. It is a healthy amount of discomfort that is beneficial to your body, like how exercise is good for your health.6 In general, it helps to detoxify the organs, rejuvenate the tissues, and cure hormonal imbalances. More specifically, here’s why you should undergo intermittent fasting:7
- To regenerate your growth hormones - this neutralizes hormonal imbalance and helps the body to generate growth hormones5 times more than the usual. These hormones aid weight loss and muscle gain.
- To improve insulin quality - intermittent fasting improves insulin sensitivity to regulate blood sugar more effectively. It also lowers your insulin levels to make body fats easier to burn for weight loss.
- To repair cells - it triggers cell repair that includes autophagy, a process where cells eat old proteins to generate newer cells.
- To aid gene expression - this corrects how your genes encode newer functions related to disease protection and longer life.
In reality, intermittent fasting helps to set the platform for the health benefits by correcting internal imbalances and restoring damaged cells and tissues first. Once the organs are in top shape, health benefits start to manifest. Here are some of the common health benefits:8
- Weight loss - it is the most obvious effect of intermittent fasting without the need for conscious restriction for the amount of calorie intake. It boosts up metabolism, burning stored calories to energy instead of converting them into fat.
- Lowered blood sugar - it reduces blood sugar level by 3-6%. This is due to the decreased insulin resistance and regulated fasting insulin levels by 20-31%, which can protect you from type 2 diabetes.
- Regulated inflammation - swelling of body parts can lead to other serious diseases. Intermittent fasting solves this by reducing monocytes, the cells found in the blood that causes inflammation. It also lowers oxidative stress to the cells to prevent inflammation.9
- Improved cardiac and brain health - it restores heart health by lowering LDL or bad cholesterol, blood triglycerides, inflammation markers, and other indicators of heart diseases. On the other hand, It improves brain health by increasing BDNF, a brain hormone that can help the growth of new nerve cells and may protect it from Alzheimer’s disease.
- Slows down aging - it delays the DNA aging and speeds up DNA repair. It also increases the level of antioxidants in the body to further fight aging. Also, animal researches found out that intermittent fasting lengthens the lifespan of rats by 36-38%.10
- Fights cancer - studies show that when it lowers insulin resistance and inflammation levels, it can help reduce cancer cells. It also improves the quality of life for people who are undergoing chemotherapy.11
If done right, intermittent fasting can unlock health benefits for a more pristine state of well-being. But before you indulge in it, listen first to your body to gauge if you can endure long hours of not eating. Or better yet, seek your physician’s advice if it suits your current health status.
IF helps the body to recover at a molecular level. This allows the bodily systems to function correctly and be more active in improving one's health.
The Science Behind Intermittent Fasting
Fasting in general affects the body on a molecular level. It neutralizes hormonal imbalances to boost metabolism and to help burn stored fat more effectively. This also activates cell repair processes to restore tissue and organ function, leading to rich health benefits. To have a closer look, here’s what happens when you fast:12
- On the 12th hour - your body enters ketosis, a state where your body starts to breakdown and burn fats. The liver converts some of these fats to ketones as a substitute energy source for the cells in the heart, brain, and skeletal muscles.
- On the 18th hour - your body turns to a full ketosis mode and continues to burn fat. The ketones then help the body to increase stress tolerance which reduces inflammation and restores damaged DNAs.
- On the 24th hour - your cells enter autophagy, allowing them to recycle old cells and break down misfolded proteins that cause diseases such as Alzheimer’s and many others.
- On the 48th hour - with a very few amounts of protein, carbs, or calories, your growth hormones escalate 5 times higher. This helps to preserve muscle mass, improve wound healing and heart health, reduce fat tissue build-up, and promote longevity.
- On the 54th hour - your body becomes more insulin-sensitive as your insulin level drops to its lowest point. This reduces inflammation, boosts your immunity to chronic diseases including cancer.
- On the 72nd hour - old immune cells are broken down to create newer ones. Your blood cell stem cells are now regenerated and your stress resistance has improved. This also shows white blood cell preservation for those who are undergoing chemotherapy.
These are fasting duration options that you can incorporate with your intermittent fasting plan. But for starters, a full-on fasting could be challenging―that’s why doing it intermittently is the way to go. It helps you eat fewer while increasing your metabolic rate by 3.6-14%, allowing your body to burn calories faster. Besides, its whole point is to bring insulin levels lower, burn fats faster, and trigger its health benefits without starving yourself.13
Fasting does great wonders to the body depending on how long the duration is. Incorporating it alternately to eating patterns helps metabolism, leading to reduced insulin levels and weight loss.
The Latest Research
A 2014 study found out that intermittent fasting can help you lose 3-8% of weight in 3 to 24 weeks, a lot more remarkable compared to other weight loss approaches. The respondents also lost 4-7% waist circumference which is a sign of a significant decrease in belly fat that is harmful to the organs and causes different diseases.14
Also, a research in 2019 proves that eating within 6 hours and fasting for the next 18 hours makes your metabolism rely on ketones instead of glucose. This means that the stored fats will be used up as an energy source for metabolism. This yields to increased longevity, stress resistance, and enhanced immunity to diseases such as obesity and cancer.15
Though it seems to be promising, studies for intermittent fasting are still in the early stages. Many other findings were either conducted on animals, small scale, or short term. This calls for the need for a higher quality of research that is primarily geared towards discovering more specific effects to the human body.16
Intermittent fasting affects the body inside and out. While proven effective by science, more studies are still needed to further prove its benefits to health.
Common Misconceptions About Intermittent Fasting
The common misconception about intermittent fasting is comparing it to starvation, which is not true. Their key differentiator is the control as to when to consume food. Starvation is an imbalance between the food you take and the energy you consume. This is due to the involuntary skipping of food intake due to illnesses and food availability. This could lead to severe suffering or even death.17
In contrast, it is voluntarily abstaining from food intake within a period of time to boost health, to keep a spiritual duty, or for other reasons. This is normally done by people who are not underweight or have enough body fat deposits to sustain energy while at fast. Doing it properly leads to health rejuvenation and will not cause suffering or death.18
Intermittent fasting is not the same as starvation. It is a conscious effort to abstain from food and aid health rejuvenation, while starvation is the involuntary absence of food that does nothing good to the body.
Intermittent Fasting vs Ketogenic Diet
Intermittent fasting and Ketogenic (or keto) diet are just two of the most popular health trends today. Both are effective for weight loss and regulating health conditions but they still differ in a lot of ways. Here are three things that make them different from each other:19
- Approach - IF is more of an eating pattern that alternates food intake with periods of fasting. Keto, on the other hand, focuses on low-carb food intake to help the body source out the calories from food that are rich in fats and proteins instead of carbohydrates.20
- Process - IF involves shortening of the eating window to allow the body to rely on stored fats for energy rather than the food taken. Keto is more on replacing carbs through consuming high-fat foods and low-starch vegetables.
- Usage - IF is best for those who want to get rid of sugar cravings and calorie counting through sticking to the eating window hours. Keto is more suitable for those who have a lot of weight to lose and can follow a strict diet based on fats and proteins to keep the body in continuous ketosis.
Both give almost the same and health benefits but many are still skeptical in doing them simultaneously. Experts debunk this by proving that keto reduces hunger and food cravings while fasting intermittently. On the side, intermittent fasting raises the level of ketones in the body allowing it to burn fat and decrease appetite. This helps the body to transition more easily to ketosis and at the same time lose more fat during the process.21
Though very enticing, intermittent fasting and keto are not for everyone. People with diabetes and heart illness should seek first the doctor’s opinion before starting IF and keto diet simultaneously. Doing so without proper guidance may lead to adverse reactions like carb-loading on non-fasting periods, fatigue, irritation, or disease complications. To add, pregnant or breastfeeding women and those who had eating disorders before should avoid intermittent fasting as it may do more harm than help.22
IF is an eating pattern while keto is a type of low-carb diet. They are proven to work well if done simultaneously but still need professional guidance to know if it fits someone’s health condition.
Techniques and Methods
Intermittent fasting comes into different alternating patterns of fasting and eating. The main thing that you have the most control of is chunking the time of the day (or days of the week) that you want to allocate for abstaining from food. Here are some of the popular methods that you can choose from:
- The 16/8 method: also known as the Leangains method that requires skipping breakfast and restricting food intake within 8 hours and followed by a 16-hour fast.
- Eat-stop-eat: this involves skipping meals for 24 hours for once or twice a week then breaking the fast right after.
- The 5:2 diet: this is taking only 500-600 calories within two non-consecutive days in a week and eating at your normal pace for the other 5 days.
The 16/8 method is probably the most popular among the three as it is the most attainable method for everyone. But take note, regardless of the IF method you choose, eating excessively on non-fasting periods defeats their purpose, so make sure to still keep track of your calorie intake when you break your fasting.23
Intermittent fasting has different forms that involve portioning hours or days for fasting periods. Regardless of the method, keeping track of calorie intake is still necessary to make your IF method of choice effective.
Who Should Not Fast?
As mentioned, intermittent fasting is not for everyone. Doing it without knowing your current health condition and at the same time, if you’re not informed how to do it properly, you might just harm your body. To give you a heads up, here are the conditions that might not work well with IF:24
- Underweight or have eating disorders - it might harm you if your BMI is below 18.5 as your body still needs fats to absorb vitamins and nutrients. It might also worsen eating disorders like anorexia and bulimia, or may even lead to other serious illnesses.
- Pregnant or breastfeeding - it is not recommendable to women who are conceiving a child or currently breastfeeding because food intake will be limited and the nutrients might fall insufficient to sustain both the mom and the child.
- Still a child or below 18 - the body is still developing at this state and limiting the food intake might not provide the necessary nutrients to aid growth.
These don’t mean that you can’t do intermittent fasting anymore. To be more certain, consult your doctor for the best health method to aid your fitness. Meanwhile, getting doctor’s opinion is a must once you decided to undergo IF but also have these medical conditions:25
- Diabetes
- High blood sugar level
- Low blood pressure
- Under medication
- Underweight
- Pregnant/breastfeeding
- Has a history of amenorrhea
You can never go wrong with IF. Problems only arise if you indulge in it without the proper guidance while being unfit for it. Remember that it is a conscious choice to take this eating pattern so better yet do it correctly with your doctor’s advice for you to avoid side effects.25
Intermittent fasting might make or break your well-being, depending on your current health status. Consult a physician first before starting to know if you are fit to undergo this fitness method.
Main Takeaway
With all these being said, intermittent fasting proves to be an effective fitness trend not just for weight loss but also for regulating known diseases. Though beneficial to the body, it still has potential dangers to health if done without proper caution. To avoid this, asking your doctor's opinion is very important to help you gauge if you are fit to undergo intermittent fasting or not.